Xylazine/Ketamine is a suitable alternative to Somnotol for surgical procedures such as gonadectomies, which can be completed in 20 minutes.
Ketamine is available as Ketalean (100mg/ml). Xylazine is availble as Rompum (20mg/ml).
The suggested dose according to MUN Animal care is 90 mg/kg Ketamine and 10 mg/Kg Xylazine administered in a single IP injection. The sex of the rat was not specified, so this dose is taken to be appropriate for both male and female rats.
We generally use a lower dose for female rats (and have also used this lower
dose successfully in young males). We use 70
mg/Kg ketamine and 7 mg/Kg Xylazine
combined in a single IP injection. The following table provides injection
volumes calculated on the basis that the initial concentrations of the ketalean and Rompum solutions are
100mg/ml and 20 mg/ml respectively.
|
Weight(gm) |
Ketalean
(ml) |
Rompum
(ml) |
Total (ml) |
|
170 |
0.12 |
0.06 |
0.18 |
|
180 |
0.13 |
0.06 |
0.19 |
|
190 |
0.13 |
0.07 |
0.20 |
|
200 |
0.14 |
0.07 |
0.21 |
|
210 |
0.15 |
0.07 |
0.22 |
|
220 |
0.15 |
0.08 |
0.23 |
|
230 |
0.16 |
0.08 |
0.24 |
|
240 |
0.17 |
0.08 |
0.25 |
|
250 |
0.18 |
0.09 |
0.27 |
|
260 |
0.18 |
0.09 |
0.27 |
|
270 |
0.19 |
0.09 |
0.28 |
|
280 |
0.20 |
0.10 |
0.30 |
|
290 |
0.20 |
0.10 |
0.30 |
|
300 |
0.21 |
0.10 |
0.31 |
|
310 |
0.22 |
0.11 |
0.33 |
|
320 |
0.22 |
0.11 |
0.33 |
|
330 |
0.23 |
0.12 |
0.35 |
|
340 |
0.24 |
0.12 |
0.36 |
|
350 |
0.24 |
0.12 |
0.36 |
Rompum and Ketalean
can be purchased from CDMV Inc., 2999 Ave Choquette,
C.P.Box 608,
Last
modified